Impact of non-communicable diseases on immunity and Ojas focussing on type 2 Diabetes Mellitus – A scoping review
DOI:
https://doi.org/10.55718/kja.204Keywords:
Non-communicable diseases, Immunity, Ojas, Type 2 Diabetes Mellitus, Gut microbiomeAbstract
Non communicable diseases (NCDs)are recognised as a major challenge in sustainable development. Among different types of NCDs, diabetes is connected to a number of other serious health problems. The projected rapid increase in diabetes prevalence, incidence, morbidity and mortality shows the necessity of developing new treatment strategies to combat the problem. In addition, diabetic patients are more susceptible to infections like urinary tract infections, lower respiratory tract infections and skin and soft tissue infections. Various studies were conducted to define the diabetes- associated mechanisms that impair the host’s defence against pathogens. These mechanisms mainly include defects in phagocytosis, suppression of cytokine production, failure to kill microbes, dysfunction of immune cells etc. Both innate and adaptive immunity are severely hampered in diabetes. The disease severity is associated with severe gut microbiota dysbiosis. In Ayurveda classics, ojakshayais described in the pathogenesis of madhumeh aand there is both qualitative and quantitative kshaya of aparaojas. This article discusses about different effects of T2DM on immune system which in turn promotes the different infections, gut microbiota dysbiosis and status of ojakshaya in Prameha.
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